Essential Mixed Cryoglobulinemia
Source: Hepatits C Awareness Project
<snip, from a larger article on Hep C conditions
Essential Mixed Cryoglobulinemia - Essential mixed cryoglobulinemia is a rare
autoimmune disorder that may involve the blood and various other
tissues and organs. The major symptoms include unusual response to cold, skin
abnormalities, blood disorders and generalized weakness. There may also be joint
pain, inflamed blood vessels, and kidney problems.
The exact cause of the essential mixed cryoglobulinemia is not known. However,
it is considered to be an autoimmune disorder. (Autoimmune disorders are caused
when the body's immune system, which is meant to defend the body against
bacteria, viruses, and any other foreign product, malfunctions and produces
antibodies against health tissue, cells and organs.) In this condition, the
immune system appears to be triggered by cold temperatures.
Cryoglobulins are proteins in the blood that become apparent when the blood is
cooled. These cryoglobulins can affect many different bodily systems, causing
pain and dysfunction. It is important to note that a link between
cryoglobulinemia and Hepatitis B infection is possible.
The most effective treatment for cryoglobulinemia associated with hepatitis C
has not yet been determined. Brief use of prednisone followed by 6 months of
interferon alfa has produced clinical and liver function test improvement, but
relapse of the liver disease and vasculitis often occurs when interferon alfa is
stopped.
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